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Food Science & Environmental Health

Grangegorman

Food Science & Environmental Health

Grangegorman



Dr. Bilal Javed

Image for Dr. Bilal Javed

Assistant Lecturer in Biochemistry (Industrial Biotechnology)

Email: bilal.javed@tudublin.ie

Research Gate: https://www.researchgate.net/profile/Bilal-Javed-12

LinkedIn: www.linkedin.com/in/bilal-javedtudublin

ORCID: https://orcid.org/0000-0002-9566-1498

Google Scholar: https://scholar.google.com/citations?user=OZb7XCYAAAAJ&hl=en

Background:

Dr. Bilal Javed is an Assistant Lecturer (Assistant Professor, below the bar) in Biochemistry (Industrial Biotechnology) at the School of Food Science and Environmental Health, Technological University Dublin (TU Dublin). He earned his PhD in Biology from Arid Agriculture University, Rawalpindi, Pakistan, with a research focus on the organic synthesis of supramolecular assemblies and the development of nanomaterials for biomedical applications. As part of his PhD research, Bilal moved to the University of Pennsylvania’s Department of Chemistry under the supervision of Professor Dr. Virgil Percec, where he worked on the synthesis and self-assembly of organic vesicles (dendrimersomes) for targeted drug delivery. His research also involved the bioinspired synthesis of surface-modified glycodendrimers and their assembly into glycodendrimersomes to mimic natural cell surfaces, enabling the study of glycan-galectin interactions that are not possible to study by using living cells. After completing his PhD, Bilal joined TU Dublin as a Marie Skłodowska-Curie Postdoctoral Fellow under the supervision of Dr. Furong Tian. He also holds a Postgraduate Certificate in University Learning and Teaching and is currently pursuing a Master’s in Pharmaceutical Quality Assurance and Regulation at TU Dublin. Dr. Javed is committed to advancing interdisciplinary research aligned with the United Nations Sustainable Development Goals, focusing on health, well-being, and environmental protection, as well as contributing to Ireland’s national research priorities as part of the Impact 2030 strategy.

Education:

  • Bachelor of Science (2009), University of The Punjab, Pakistan
  • Bachelor of Science Education (2015), University of The Punjab, Pakistan
  • Master of Science in Botany (2011), PMAS Arid Agriculture University Rawalpindi, Pakistan
  • Phil. in Biological Sciences (2014), University of Gujrat, Pakistan
  • Master of Science in Pharmaceutical Quality Assurance and Regulation (2022-in-process), Technological University Dublin Ireland.
  • PhD in Biological Sciences, (2020) PMAS Arid Agriculture University Rawalpindi, Pakistan and The University of Pennsylvania Philadelphia, USA
  • Marie-Sklodowska Curie Postdoctoral Research Fellow (2021-2024), Technological University Dublin, Dublin, Ireland
  • Postgraduate Certificate in University Learning and Teaching (2023), Technological University Dublin Ireland.

 

Research Overview:

Bilal leads a multidisciplinary research group to develop novel biomimetic drug-delivery supramolecular assemblies and 3D cell culture platforms to deepen the understanding of the efficacy of drug-delivery systems. These systems enhance drug biocompatibility and minimize the risk of triggering immune responses. The team focuses on understanding the fundamental self-assembly processes and developing efficient strategies for drug encapsulation and release. Through their expertise in synthetic amphiphilic lipids, Bilal’s group applies this knowledge to create advanced biomedical platforms, aimed at delivering therapeutic agents with precision and control. Additionally, we also investigate the use of the 3D cell models in the microfluidic devices for the establishment of the lab-on-a-chip platforms for the investigation of novel therapeutics and understanding the mechanisms of cancer metastasis which are critical in developing next-generation cancer therapies.

In addition to drug delivery systems, Bilal’s research group focuses on advancing biosensing technologies using novel nanomaterials. By modifying these nanomaterials, the team enhances the sensitivity and accuracy of multiplex platforms designed for rapid pathogen detection, which is crucial for early disease diagnosis and preventing food contamination. This research holds great potential for improving public health through faster and more reliable diagnostics. His team works on the development of stable conjugates of nanomaterials of different sizes with multiple antibodies for the multiplex detection of analytes. Additionally, he works on the design of haptens to improve the sensitivity of the analytes and the reproducibility of the results. Further to quantify the analyte at the point of care, the team works to combine the biosensing immunoassay with a mobile application to quantitatively correlate the color intensities with quantities of analytes. Algorithms to process the captured images and extract color intensities are being developed using image segmentation, color thresholding, and intensity measurements.

Graduate Career Opportunities:

PhD/Graduate Scholarships: ARISE TU Dublin PhD Scholarship, Government of Ireland Postgraduate Scholarship, Irish Cancer Society PhD Scholarship, Breakthrough Cancer Research Scholarship, Horizon Europe Scholarships, and Erasmus+ EU programme for education, training, youth and sport.

Postdoctoral Research Fellowships: Marie Skłodowska-Curie Actions Postdoctoral Fellowship, Irish Research Council Postdoctoral Fellowship, SFI-IRC Pathway Programme, and DOROTHY COFUND Programme. 

Teaching:

Dr. Bilal is delivering the following modules during the 2024-2025 academic session.

  • Safety Aspects of Primary Production (TFFP 9004)
  • Introduction to Manufacturing and Environmental Monitoring for Pharmaceutical Healthcare (FOOD 1004)
  • Food and Pharmaceutical Instrumentation I (TFCH 2004)
  • Food and Pharmaceutical Instrumentation II (TFCH 2005)
  • Molecular Biotechnology (TFBT 3003)
  • Fundamentals of Human Physiology (TFBG 1002)
  • Introduction to the Biotechnology Sector (BTEC 1009)
  • Introduction to Biopharmaceuticals (BIOP 1001)
  • Critical thinking for Biotechnology and related industries (FOOD 1005)

Administrative Responsibilities

Dr. Javed’s administrative duties include:

  • Year tutor of the Bachelor of Science (Honours) in Pharmaceutical Healthcare
  • Managing risk assessment procedures at the Nano Lab Research Centre, ensuring safety in research activities.

Dissemination Activities:

  • Active working member of the COST (European Cooperation in Science and Technology) Actions, CA22103 (Net4Brain), CA21145 (EURESTOP), CA21147 (ENOTTA), and CA20114 (PlasTHER).

Projects or Fundings Received

  • ARISE PhD Lead Supervisor in the thematic research area Food, Agritech., Bio-economy, & Sustainability (€134,000).

Title: Quantification of Marine Biotoxins in Seafood based on Multiplex Immunochromatography Integrating Diverse Bioreceptors and Mobile Appliance Detection (QMB-Immuno)

  • ARISE PhD Lead Supervisor in the thematic research area Biopharma, Life Sciences, & Medical Technologies (€134,000).

Title: Pre-Clinical Evaluation of Supramolecular Vesicle-Encapsulated Gold Nanoparticles in Combination with Cold Atmospheric Plasma for Brain Cancer Treatment

  • ARISE PhD Co-supervisor in the thematic research area Advanced Manufacturing & Engineering (€134,000).

Title: Developing digital Multicolour strip test based on different shaped gold nanoparticles for the determination of mycotoxin

  • Marie Skłodowska-Curie Postdoctoral Research Award from the European Commission and Enterprise Ireland (€250,000).
  • Strategic Alignment of Teaching and Learning Enhancement (SATLE) Funding 2024 from the HEA

Title: Evaluation of Artificial Intelligence Tools for Sustainable Biomanufacturing Process Development and Their Life Cycle Assessment (€5,000).

  • International Research Support Initiative Program (IRSIP) fellowship from the Higher Education Commission of Pakistan ($15,000).

Awards and Honours

  • In the year 2022, Dr Javed has been recognized among the top 2% of the most cited young scientists globally, according to a survey by Stanford University and Elsevier.

Publications:

2020

  1. Javed, B.‡, & Mashwani, Z. (2020). Synergistic Effects of Physicochemical Parameters on Bio-Fabrication of Mint Silver Nanoparticles : Structural Evaluation and Action Against HCT116 Colon Cancer Cells. International Journal of Nanomedicine, 15, 3621–3637. https://doi.org/10.2147/IJN.S254402
  2. Li, S., Xia, , Javed, B., Hasley, W. D., Melendez-davila, A., Liu, M., … Good, M. C. (2020). Direct Visualization of Vesicle Disassembly and Reassembly Using Photocleavable Dendrimers Elucidates Cargo Release Mechanisms. ACS Nano. https://doi.org/10.1021/acsnano.0c02912
  3. Javed, B.‡, Nadhman, A., & Mashwani, Z. U. R. (2020). Phytosynthesis of Ag nanoparticles from Mentha longifolia : their structural evaluation and therapeutic potential against HCT116 colon cancer, Leishmanial and bacterial cells. Applied Nanoscience. https://doi.org/10.1007/s13204-020-01428-5
  4. Javed, B.‡, Nadhman, A., Razzaq, A., & Mashwani, Z. (2020). One-pot phytosynthesis of nano-silver from Mentha longifolia L .: their characterization and evaluation of photodynamic potential. Materials Research Express, 7(5), 1–9. https://doi.org/10.1088/2053-1591/ab903b
  5. Javed, B.‡, Nawaz, K., & Munazir, M. (2020). Phytochemical Analysis and Antibacterial Activity of Tannins Extracted from Salix alba Against Different Gram-Positive and Gram-Negative Bacterial Strains. Iranian Journal of Science and Technology, Transactions A: Science, 1–12. https://doi.org/10.1007/s40995-020-00937-w
  6. Javed, B.‡, Raja, N. I., Nadhman, A., & Mashwani, Z.-R. (2020). Understanding the potential of bio-fabricated non-oxidative silver nanoparticles to eradicate Leishmania and plant bacterial pathogens. Applied Nanoscience, 10(6), 2057–2067. https://doi.org/10.1007/s13204-020-01355-5
  7. Javed, B.‡, Sarwer, A., Soto, E. B., & Mashwani, Z.-R. (2020). Impact of SARS-CoV-2 (Coronavirus) Pandemic on Public Mental Health. Frontiers in Public Health, 8, 1–4. https://doi.org/10.3389/fpubh.2020.00292
  8. Javed, B.‡, Sarwer, A., Soto, E. B., & Mashwani, Z.-R. (2020). Is Pakistan’s Response to Coronavirus (SARS-CoV-2) Adequate to Prevent an Outbreak? Frontiers in Medicine, 7. https://doi.org/10.3389/fmed.2020.00158
  9. Javed, B.‡, Soto, E. B., Sarwer, A., & Mashwani, Z.-R. (2020). The coronavirus ( COVID-19 ) pandemic’s impact on mental health. The International Journal of Health Planning and Management, 1–4. https://doi.org/10.1002/hpm.3008
  10. Javed, B.‡, Sarwer, A., Soto, E. B., & Mashwani, Z. ur R. (2020). Is Pakistan on track to have COVID-19 transmission and mortality rates similar to those of Italy, Iran or the USA? Drugs and Therapy Perspectives, 36(7), 293–297. https://doi.org/10.1007/s40267-020-00726-w
  11. Javed, B.‡, Seerat, W., Sarwer, A., & Mashwani, Z. (2020). Ethnopharmacological approaches of the native hill people of Murree and Kotli Sattian, District Rawalpindi, Province of Punjab, Pakistan. Botany Letters, 1–17. https://doi.org/10.1080/23818107.2020.1806106
  12. Javed, B.‡ (2020). Bioactive Virus-Mimicking Nanovesicles From Dendrimersomes : A Novel Approach to Understanding SARS-CoV-2 Host-Interactions to Better Design Therapeutics. Frontiers in Molecular Biosciences, 7(August), 188. https://doi.org/10.3389/fmolb.2020.00188
  13. Javed, B.‡, Nadhman, A., & Mashwani, Z. (2020). Optimization, characterization and antimicrobial activity of silver nanoparticles against plant bacterial pathogens phyto-synthesized by Mentha longifolia. Materials Research Express, 7(8), 085406. https://doi.org/10.1088/2053-1591/abaf19
  14. Sarwer, A., Javed, B.*‡, Soto, E. B., & Mashwani, Z. (2020). Impact of the COVID-19 pandemic on maternal health services in Pakistan. International Journal of Health Planning and Management, (July), 1–5. https://doi.org/10.1002/hpm.3048
  15. Javed, B.‡, & Mashwani, Z. U. R. (2020). Phytosynthesis of colloidal nanosilver from Mentha longifolia and Mentha arvensis: Comparative morphological and optical characterization. Microscopy Research and Technique, (September), 1–9. https://doi.org/10.1002/jemt.23518
  16. Javed, B.‡, Mashwani, Z., Sarwer, A., Raja, N. I., & Nadhman, A. (2020). Synergistic response of physicochemical reaction parameters on biogenesis of silver nanoparticles and their action against colon cancer and leishmanial cells. Artificial Cells, Nanomedicine, and Biotechnology, 48(1), 1340–1353. https://doi.org/10.1080/21691401.2020.1850467
  17. Ikram M, Raja NI, Javed B.‡, Mashwani Z-R, Hussain M, Hussain M, Ehsan M, Ra N, Malik K, Sultana T, Akram A. (2020) Foliar applications of bio-fabricated selenium nanoparticles to improve the growth of wheat plants under drought stress. Green Processing and Synthesis 9:706–714. https://doi.org/10.1515/gps-2020-0067

2021

  1. Murphy P V., Romero A, Xiao Q, Ludwig A-K, Jogula S, Shilova N V., Singh T, Gabba A, Javed B, Zhang D, Medrano FJ, Kaltner H, Kopitz J, Bovin N V., Wu AM, Klei ML, Percec V, Gabius H-J. (2021) Probing Sulfatide-Tissue Lectin Recognition with Functionalized Glycodendrimersomes. iScience https://doi.org/10.1016/j.isci.2020.101919
  2. Ikram, M., Javed, B.*‡, Raja, N. I., & Mashwani, Z.-R. (2021). Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects. International Journal of Nanomedicine, 16, 249–268. https://doi.org/10.2147/IJN.S295053
  3. Ahmed, F., Javed, B.*‡., Razzaq, A., & Zia‐ur‐Rehman Mashwani. (2021). Applications of copper and silver nanoparticles on wheat plants to induce drought tolerance and increase yield. IET Nanobiotechnology, 1–11. https://doi.org/10.1049/nbt2.12002
  4. Satti, S. H., Raja, N. I., Javed, B.‡, Akram, A., Mashwani, R., Ahmad, M. S., & Ikram, M. (2021). Titanium dioxide nanoparticles elicited agro- morphological and physicochemical modifications in wheat plants to control Bipolaris sorokiniana. PLoS ONE, 16(2), e0246880. https://doi.org/10.1371/journal.pone.0246880
  5. Javed, B.‡, Ikram, M., Farooq, F., Sultana, T., Zia-ur-Rehman, M., & Raja, N. I. (2021). Biogenesis of silver nanoparticles to treat cancer, diabetes, and microbial infections : a mechanistic overview. Applied Microbiology and Biotechnology, 1–15. https://doi.org/10.1007/s00253-021-11171-8
  6. Ikram, M., Javed, B.‡*, Hassan, S. W. U., Satti, S. H., Sarwer, A., Raja, N. I., & Mashwani, Z.-R. (2021). Therapeutic potential of biogenic titanium dioxide nanoparticles: a review on mechanistic approaches. Nanomedicine, 1–18. https://doi.org/10.2217/nnm-2021-0020
  7. Sultana, T., Javed, B.‡*, Raja, N. I., & Mashwani, Z.-R. (2021). Silver nanoparticles elicited physiological, biochemical, and antioxidant modifications in rice plants to control Aspergillus flavus. Green Processing and Synthesis, 10(1), 314–324. https://doi.org/10.1515/gps-2021-0034
  8. Khan, M. F., Mahmood, M., Hasrat, M. N., Javed, B., & Javed, O. (2021). Perception, preparedness and response of health care personals towards COVID-19 pandemic in Azad Jammu & Kashmir, Pakistan: A cross sectional interview based study. Clinical Epidemiology and Global Health, 100783. https://doi.org/10.1016/j.cegh.2021.100783
  9. Batool, S. U., Javed, B. ‡*, Sohail, Zehra, S. S., Mashwani, Z., Raja, N. I., … Alamri, S. (2021). Exogenous Applications of Bio-fabricated Silver Nanoparticles to Improve Biochemical, Antioxidant, Fatty Acid and Secondary Metabolite Contents of Sunflower. Nanomaterials, 11(7), 1750. https://doi.org/10.3390/nano11071750
  10. Javed, B.‡, Zhao, X., Cui, D., Curtin, J., & Tian, F. (2021). Enhanced Anticancer Response of Curcumin- and Piperine-Loaded Lignin-g-p (NIPAM-co-DMAEMA) Gold Nanogels against U-251 MG Glioblastoma Multiforme. Biomedicines, 9(11), 1516. https://doi.org/10.3390/biomedicines9111516
  11. Shah, S. A., Iqbal, W., Sheraz, M., Javed, B. ‡, Zehra, S. S., Abbas, H. A. B. E., … Mashwani, Z. (2021). Ethnopharmacological Study of Medicinal Plants in Bajwat Wildlife Sanctuary, District Sialkot, Punjab Province of Pakistan. Evidence-Based Complementary and Alternative Medicine, 2021, 5547987. https://doi.org/10.1155/2021/5547987
  12. Javed, B. ‡, Farooq, F., Ibrahim, M., Abbas, H. A. B., Jawwad, H., Zehra, S. S., … Nawaz, K. (2023). Antibacterial and antifungal activity of methanolic extracts of Salix alba L. against various disease causing pathogens. Brazilian Journal of Biology, 83, 1–10. https://doi.org/10.1590/1519-6984.243332 `2022
  13. Sharma, V., Javed, B., Byrne, H., Curtin, J., & Tian, F. (2022). Zeolites as Carriers of Nano-Fertilizers: From Structures and Principles to Prospects and Challenges. Applied Nano, 3(3), 163–186. https://doi.org/10.3390/applnano3030013
  14. Zhao, X., Javed, B., Tian, F., & Liu, K. (2022). Hydrogel on a Smart Nanomaterial Interface to Carry Therapeutics for Digitalized Glioma Treatment. Gels, 8(10), 664. https://doi.org/10.3390/gels8100664 (IF: 4.432)
  15. Zhao, X., Smith, G., Javed, B., Dee, G., Gun’ko, Y. K., Curtin, J., Byrne, H. J., O’Connor, C., & Tian, F. (2022). Design and Development of Magnetic Iron Core Gold Nanoparticle-Based Fluorescent Multiplex Assay to Detect Salmonella. Nanomaterials, 12(21), 3917. https://doi.org/10.3390/nano12213917

2023

  1. Moors, E., Sharma, V., Tian, F., & Javed, B*. (2023). Surface-Modified Silver Nanoparticles and Their Encapsulation in Liposomes Can Treat MCF-7 Breast Cancer Cells. Journal of Functional Biomaterials, 14(10), 509. https://doi.org/10.3390/jfb14100509
  2. Shahjahan, T., Javed, B. ‡*, Sharma, V., & Tian, F. (2023a). Overview of Various Components of Lateral-Flow Immunochromatography Assay for the Monitoring of Aflatoxin and Limit of Detection in Food Products: A Systematic Review. Chemosensors, 11(10), 520. https://doi.org/10.3390/chemosensors11100520
  3. Shahjahan, T., Javed, B. ‡*, Sharma, V., & Tian, F. (2023b). pH and NaCl Optimisation to Improve the Stability of Gold and Silver Nanoparticles’ Anti-Zearalenone Antibody Conjugates for Immunochromatographic Assay. Methods and Protocols, 6(5), 93. https://doi.org/10.3390/mps6050093
  4. Sharma, V., Javed, B.‡*, Estrada, G., Byrne, H. J., & Tian, F. (2024). In situ tuning and investigating the growth process of size controllable gold nanoparticles and statistical size prediction analysis. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 681, 132733. https://doi.org/10.1016/j.colsurfa.2023.132733

2024

  1. Naik, A. S., Brugiere, M., Dunne, K., Sorohan, M., Grasa, L., & Javed, B. (2024). Protease hydrolysed brewers’ spent grain bioactive extracts for applications in human health. Systems Microbiology and Biomanufacturing. https://doi.org/10.1007/s43393-024-00241-3
  2. Thenuwara, G., Javed, B., Singh, B., & Tian, F. (2024). Enhanced Organ-on-a-Chip Models for Investigating Glioblastoma Tumor Microenvironment Dynamics. Biosensor. https://doi.org/10.3390/s24092865

*Equally Shared First Author, ‡ Corresponding Author

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